Postdoctoral Fellow in Biochemistry and Molecular Biology (2020-00410)
Postdoctoral fellowship in biophysics and structural biology of signaling kinases and membrane transporters
We are looking for highly motivated applicants for a postdoctoral fellow in the Edward A. Doisy Department of Biochemistry and Molecular Biology at Saint Louis University, beginning in the spring of 2020. Successful candidates are expected to have a doctoral degree in chemistry, biochemistry, or biophysics, with research experience in structural biology/spectroscopy (EPR spectroscopy, Electron Cryomicroscopy, or X-ray crystallography). The lab focuses on the molecular understanding of the cellular release mechanism of the brain-type creatine kinase and sphingosine kinase isoforms 1 and 2 as key therapeutic targets in a wide variety of neoplastic, cardiovascular, and neurodegenerative diseases. In addition, the lab investigates the structural dynamics of membrane transporters associated with the survival of metastatic cells. Projects will combine EPR restraint-assisted modeling with other structural studies. Applicants should be able to think critically and demonstrate productivity throughout previous research experiences. Compensation will be competitive based on experience.
The Doisy Research Center EPR facility is equipped with an EMX X-band continuous-wave (CW) EPR spectrometer, and a Bruker ELEXSYS E580 pulse EPR spectrometer capable of pulse and CW EPR spectroscopy at both X and Q-bands, as well as a variety of ELDOR and ENDOR spectroscopies. The candidate will have access to a Phoenix robotic instrumentation from Art Robbins Instruments for the preparation, screening, and imaging of crystals and two Rigaku X-ray generators for the collection of high-resolution data on macromolecular samples (https://biochem.slu.edu/facilities-resources/). Cryo-EM images will be collected on a state-of-the-art Titan Krios G3 300kV Cryo-TEM available at our affiliated WUCCI center (https://wucci.wustl.edu/facilities/cryo-em/).