HFSP-funded Postdoc Position in EPR Spectroscopy

The Molecular Biomechanics group at the Heidelberg Institute for Theoretical Science and the IMSEAM, Heidelberg University, seeks a postdoctoral fellow to investigate protein mechanoradicals.

The overarching aim of the HFSP project is to test our hypothesis that mechanically- generated radicals form within the extracellular matrix of living systems and affect their physiology. You will closely collaborate with the labs of Ronen Zaidel-Bar, Tel Aviv University, and Alex Dunn, Stanford University, where our hypothesis will be tested in two different in- vivo model. The ultmate goal is to establish mechanoradicals as a hitherto unrecognized molecular species in life that converts tension into chemical signals, with implications for tissue homeostasis, organism health and ageing.

The aim of your project is to uncover the biophysical principles of mechanoradical forma8on and downstream signalling. To this end, you will employ Electron paramagnetic resonance (EPR) spectroscopy methods, tissue rheology, redox biochemistry techniques. If interested, you can combine these with machine learning and molecular simulation methods we develop in our group. Your work will be tightly linked to our ongoing efforts within our ERC project RADICOL.

Your profile

• PhD degree in biochemistry, biophysics, or related fields

• Solid skills in EPR spectroscopy
• Strong interest in protein radicals and their fate
• Enthusiasm for international teamwork

We are a highly interdisciplinary and diverse group of scientists and provide an excellent and collaborative research environment. Please reach out for any further questions. Send your CV, your publication list, a short research statement, and contact info for three referees to Frauke Graeter: [email protected]

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